Table 1 Genes/proteins involved in primary cilia trafficking
ITF particle/component | IFT20, Elipsa |
Rab GTPases | Rab5, Rab6, Rab8, Rab10, Rab11, Rab23 |
Arf/Arl GTPases | ARF4, ARL3, ARL6, ARL13, ARL13b |
Guanosyl nucleotide exchange factor | Rabin8 (Rab8) |
GTPase activating protein | RP2 (ARL3), ASAP1 (Arf4) |
Rab effectors | Rabaptin5 (Rab5), FIP3 (Rab11) |
Clathrin adaptor | AP-1 |
Exocyst | Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, Exo84 |
BBSome | BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9, BBIP10 |
TRAPPII complex | TRAPPC1, TRAPPC2, TRAPPC3, TRAPPC4, TRAPPC5, TRAPPC6A, TRAPPC6B, TRAPPC9, TRAPPC10 |