Figure 3

Diagrammatic overview of Wnt involvement with the cytoskeleton. Transport of APC by kinesin motors plays an important role in microtubule stabilization, activation of protein kinases and cell polarization, which could all be regulated via the Gsk3β kinase. Phosphorylation of kinesins via kinases controls their sub-cellular localization and activity. Gsk3β is one of the central kinases predominantly associated with Wnt signaling and may influence many functions of kinesins through regulating cargo binding. Phospohrylation of APC by Gsk3β decreases the interaction of APC with microtubules, subsequently decreasing microtubule stability. Gsk3β could be considered a master regulator of kinesin control over MT dynamics, due to its ability to regulate a range of kinesins.