Figure 4
From: Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis
Cilia length in control of cell cycle progression. Cilia provide a physical block for cell cycle progression by laying claim to the basal body. Disassembly of the primary cilium is required to liberate the centrosome and allow duplication during S-phase and subsequent formation of the mitotic spindle during chromosomal segregation. Cilia mutants that inhibit ciliogenesis are prone to initiate rapid cell duplication when properly stimulated, and in contrast, increased axonemal length delays cell cycle progression. The maturation steps (growth and appendages) of the centrioles are indicated during the various cell cycle stages.