Figure 5

The mammary phenotype in Prx1-Cre; Ift88^Delmice is likely due to systemic factors. Whole mount Carmine staining of #4 mammary glands from 4 week old control (A) and Prx1-Cre; Ift88^Del (B) mice. Control (C,D) and Prx1- Cre; Ift88^Del (E,F) mammary glands were transplanted onto 3 week old Ift88- positive Scid mice. Transplants were removed after 4 weeks and stained with Carmine. Low (C,E) and high (D,F) magnification images are shown. Representative terminal end buds are marked with arrows (D,F). Carmine stained whole mounts from control (G) and Prx1-Cre; Ift88^Del (H) transplants were then sectioned and stained with H&E.