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Fig. 3 | Cilia

Fig. 3

From: Comparing the Bbs10 complete knockout phenotype with a specific renal epithelial knockout one highlights the link between renal defects and systemic inactivation in mice

Fig. 3

Retinal phenotype in Bbs10 −/− mice. a Optical coherence tomography (OCT) pictures of retinas from Bbs10 +/+ and Bbs10 −/− mice. (OS outer segment, IS inner segment, ONL outer nuclear layer) (n = 3 mice per genotype). b Toluidine blue-stained pictures of 7-µm-thick retinal sections from Bbs10 +/+ and Bbs10 −/− mice (OS outer segment, IS inner segment, ONL outer nuclear layer, OPL outer plexiform layer, INL inner nuclear layer, IPL inner plexiform layer) Scale bar 20 µm. c Immunofluorescence of 7-µm-thick retinal sections from Bbs10 +/+ and Bbs10 −/− mice. Nuclei were counterstained with DAPI (blue), rhodopsin (green), acetylated a-tubulin (red). d Transmission electron microscopy (T.E.M.) pictures of retinal sections in Bbs10 +/+ and Bbs10 −/− mice (ROS retinal outer segment, RIS retinal inner segment, RPE retinal pigment epithelium). Red arrows indicate the centrioles and the connecting cilium. e Scotopic electroretinograms (ERG) recordings of 2- and 3-month-old Bbs10 +/+ and Bbs10 −/− mice. Red arrows indicate a-waves on the ERG recordings (n = 6–8 per genotype).

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Cilia

ISSN: 2046-2530

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