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Table 3 Status of proteasomal activity in different cancer types

From: The cilia-regulated proteasome and its role in the development of ciliopathies and cancer

Cancer type

Cancer cell type

Status of proteasomal activity

References

Increased proteasomal activity

Reduced proteasomal activity

Bladder cancer

Human bladder cancer cells; human T24 urinary bladder carcinoma cell line

X

 

[75–77]

Brain tumor

GBM stem-like cells; temozolomide-resistant glioma cell lines

X

 

[104]

Breast cancer

MCF-7 and MDA-MB-231 human breast cancer cells

X

 

[78]

Cancer stem cells

Various cancer stem cells; human head and neck squamous cell carcinoma (HNSCC) cells; breast cancer stem cells (BCSCs)

 

X

[98–103]

Colon cancer

HCT116 colon adenocarcinoma cells; metastatic colorectal cancer tissue

X

 

[79, 80]

Lung cancer

Lung cancer cell lines (H460, A549 and H129)

X

 

[81, 82]

Skin cancer

Various human and mouse tumor cell lines

X

 

[84]

Ovarian cancer

Various ovarian cancer cell lines

X

 

[83]

Pancreatic cancer

MIA-PaCa-2 human pancreatic cancer cells

X

 

[85]

Prostate cancer

LNCaP (AD) and PC3 (AI) PCa cells

X

 

[86]

Renal cancer

Renal cell carcinoma tissue; clear cell renal cell carcinoma (CCRCC) cell lines

X

 

[87–89]