Table 1 Proteomic, RNAi and genomic screens that identified Drosophila centriole or centrosome proteins
From: Drosophila melanogaster as a model for basal body research
Type of screen | System | Proteins identified | References |
|---|---|---|---|
Genetic screen for mechanosensation defects | In vivo genetic screen | Unc, Asterless (MecD), Cep290 (MecH) | |
Genetic screen for male infertility | In vivo genetic screen | Asterless, Spd-2 | |
RNAi | Cell culture | Ana1, Ana2, Ana3 | [66] |
RNAi | Cell culture | Bld10, CP110, Cep97, Rcd4 | [67] |
Proteomic | Mature sperm | Ana1, Ana3, Asp, Bld10, Grip163, Ninein, Plp, Rootletin | [60] |
Proteomic | Isolated blastoderm embryo centrosomes | CG11148, Cort, Crm, eIF-4a, Feo, Lam, Nup153, TFAM | [68] |
Proteomic | Isolated blastoderm embryo centrosomes | Ote; new phosphorylation sites mapped in known centrosome proteins | [69] |