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Fig. 3 | Cilia

Fig. 3

From: Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure

Fig. 3

Neurotoxic Amyloid-β disrupts canonical Sonic hedgehog signal transduction. a Gli-mediated luciferase activity of NIH3T3 Shh-Light2 cells treated with 100 nM SAG or in combination with 5 μM cyclopamine for 24 h. Quantification represents Gli-mediated luciferase activity normalized to vehicle control treated cells. b Gli-mediated luciferase activity of NIH3T3 Shh-Light2 cells treated with indicated concentrations of synthetic human Aβ42 peptide for 24 h. c LDH cytotoxicity analysis of NIH3T3 Shh-Light2 cells treated with Aβ42 peptide for 24 h. d Gli-mediated luciferase activity of NIH3T3 Shh-Light2 cells treated with SAG and increasing concentrations of Aβ42 peptide for 24 h. Values denote mean ± standard errors of the means. Student’s t test was used for statistical analysis: ***p < 0.005, **p < 0.01, *p < 0.05

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