Fig. 5From: Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structureCartoon illustration of a possible mechanism for APP sensing Aβ at the primary cilium. On the right, disrupted primary cilium structure due to increased Aβ levels leads to interrupted Sonic hedgehog signaling, abolished secretion of survival factors, and increased AICD-mediated transcriptional activation pro-amyloidogenic genes and the Shh negative regulator PTCH1Back to article page