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Fig. 10 | Cilia

Fig. 10

From: Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles

Fig. 10

Arl13b overexpression leads to abnormal SMO enrichment in GBM cell cilia. Confocal images of a cultured L0 cells untreated or exposed to SHH [1 μg/ml] and immunostained for ARL13B (green), SMO (red), and aaTub (blue) and b Arl13b:GFP+ clones co-stained for SMO (red) and aaTub (blue). L0 GBM cells that had been exposed to SHH and Arl13b:GFP+ clones displayed SMO (arrows) that was colocalized with Arl13b+/aaTub+ cilia. c Percentage of cells with SMO+ cilia in untreated, DMSO-treated, SHH-treated L0 wild-type (WT) cells, and Arl13b:GFP+ clone D4

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