Figure 4
From: Molecular connections between nuclear and ciliary import processes
A ciliary localization sequence regulates ciliary localization of the kinesin-2 motor KIF17. Full-length KIF17 can enter the ciliary compartment whereas a truncation that removes the tail domain (KIF17Δtail) abolishes ciliary localization. When expressed as a fragment, the KIF17 tail domain localizes to both the ciliary (inset top, cilia immunostained with acetylated tubulin antibody in red) and nuclear (inset bottom, nucleus stained with DAPI in blue) compartments, due to the presence of a sequence that can act as a ciliary localization sequence and nuclear localization sequence.