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  1. Cilia emanate from basal bodies just underneath the cell membrane. Basal bodies must withstand torque from the ciliary beat and be appropriately spaced for cilia to beat in metachronal waves. Basal body rootle...

    Authors: Ashikun Nabi, Junji Yano, Megan S. Valentine, Tyler Picariello and Judith L. Van Houten
    Citation: Cilia 2019 8:2
  2. Primary cilia frequency and length are key metrics in studies of ciliogenesis and ciliopathies. Typically, quantitative cilia analysis is done manually, which is very time-consuming. While some open-source and...

    Authors: Max C. Lauring, Tianqi Zhu, Wei Luo, Wenqi Wu, Feng Yu and Derek Toomre
    Citation: Cilia 2019 8:1
  3. A transient increase in cytosolic Ca2+ (the “Ca2+ transient”) determines the degree and duration of myocyte force development in the heart. However, we have previously observed that, under the same experimental c...

    Authors: Sarbjot Kaur, Sue R. McGlashan and Marie-Louise Ward
    Citation: Cilia 2018 7:4
  4. Primary cilia mediate signal transduction by acting as an organizing scaffold for receptors, signalling proteins and ion channels. Ciliated olfactory sensory neurons (OSNs) organize olfactory receptors and ion...

    Authors: Judith G. M. Bergboer, Cameron Wyatt, Christina Austin-Tse, Emre Yaksi and Iain A. Drummond
    Citation: Cilia 2018 7:2
  5. Mainzer–Saldino syndrome (MZSDS) is a skeletal ciliopathy and part of the short-rib thoracic dysplasia (SRTD) group of ciliary disorders. The main characteristics of MZSDS are short limbs, mild narrow thorax, ...

    Authors: Machteld M. Oud, Brooke L. Latour, Zeineb Bakey, Stef J. Letteboer, Dorien Lugtenberg, Ka Man Wu, Elisabeth A. M. Cornelissen, Helger G. Yntema, Miriam Schmidts, Ronald Roepman and Ernie M. H. F. Bongers
    Citation: Cilia 2018 7:1
  6. Recent research into ciliary structure and function provides important insights into inherited diseases termed ciliopathies and other cilia-related disorders. This wealth of knowledge needs to be translated in...

    Authors: Paola Roncaglia, Teunis J. P. van Dam, Karen R. Christie, Lora Nacheva, Grischa Toedt, Martijn A. Huynen, Rachael P. Huntley, Toby J. Gibson and Jane Lomax
    Citation: Cilia 2017 6:10
  7. Cilia appear to be derived, evolutionarily, from structures present in the ancestral (pre-ciliary) eukaryote, such as microtubule-based vesicle trafficking and chromosome segregation systems. Experimental obse...

    Authors: Tristan D. McClure-Begley and Michael W. Klymkowsky
    Citation: Cilia 2017 6:8
  8. Skeletal ciliopathies comprise a spectrum of ciliary malfunction disorders that have a profound effect on the skeleton. Most common among these disorders is short rib polydactyly syndrome (SRPS), a recessively...

    Authors: Ivan Duran, S. Paige Taylor, Wenjuan Zhang, Jorge Martin, Faisal Qureshi, Suzanne M. Jacques, Robert Wallerstein, Ralph S. Lachman, Deborah A. Nickerson, Michael Bamshad, Daniel H. Cohn and Deborah Krakow
    Citation: Cilia 2017 6:7
  9. The development of a ciliary axoneme requires the correct docking of the basal body at cytoplasmic vesicles or plasma membrane. In the multiciliated cell Paramecium, three conserved proteins, FOR20, Centrin 2, an...

    Authors: Hakim Bengueddach, Michel Lemullois, Anne Aubusson-Fleury and France Koll
    Citation: Cilia 2017 6:6
  10. La-related protein 6 (LARP6) is an evolutionally conserved RNA-binding protein. Vertebrate LARP6 binds the 5′ stem-loop found in mRNAs encoding type I collagen to regulate their translation, but other target m...

    Authors: Zarko Manojlovic, Ryan Earwood, Akiko Kato, Diana Perez, Oscar A. Cabrera, Ruth Didier, Timothy L. Megraw, Branko Stefanovic and Yoichi Kato
    Citation: Cilia 2017 6:4
  11. Three-dimensional explant spheroid formation is an ex vivo technique previously used in studies of airway epithelial ion and water transport. Explanted cells and sheets of nasal epithelium form fully different...

    Authors: June Kehlet Marthin, Elizabeth Munkebjerg Stevens, Lars Allan Larsen, Søren Tvorup Christensen and Kim Gjerum Nielsen
    Citation: Cilia 2017 6:3
  12. The discovery of disease pathogenesis requires systematic agnostic screening of multiple homeostatic processes that may become deregulated. We illustrate this principle in the evaluation and diagnosis of a 5-y...

    Authors: Megan S. Kane, Mariska Davids, Michelle R. Bond, Christopher J. Adams, Megan E. Grout, Ian G. Phelps, Diana R. O’Day, Jennifer C. Dempsey, Xeuli Li, Gretchen Golas, Gilbert Vezina, Meral Gunay-Aygun, John A. Hanover, Dan Doherty, Miao He, May Christine V. Malicdan…
    Citation: Cilia 2017 6:2
  13. This is a history of cilia research before and after the discovery of intraflagellar transport (IFT) and the link between primary cilia ciliogenesis and polycystic kidney disease (PKD). Before IFT, ca. the beg...

    Authors: Peter Satir
    Citation: Cilia 2017 6:1
  14. Nearly all cells have a primary cilia on their surface, which functions as a cellular antennae. Primary cilia assembly begins intracellularly and eventually emerges extracellularly. However, current ciliogenes...

    Authors: Ira Kukic, Felix Rivera-Molina and Derek Toomre
    Citation: Cilia 2016 5:23
  15. The fruit fly, Drosophila melanogaster, is one of the most extensively studied organisms in biological research and has centrioles/basal bodies and cilia that can be modelled to investigate their functions in ani...

    Authors: Swadhin Chandra Jana, Mónica Bettencourt-Dias, Bénédicte Durand and Timothy L. Megraw
    Citation: Cilia 2016 5:22
  16. The unicellular green alga, Chlamydomonas reinhardtii, is a biflagellated cell that can swim or glide. C. reinhardtii cells are amenable to genetic, biochemical, proteomic, and microscopic analysis of its basal b...

    Authors: Susan K. Dutcher and Eileen T. O’Toole
    Citation: Cilia 2016 5:18
  17. Phylum choanoflagellata is the nearest unicellular neighbor of metazoa at the phylogenetic tree. They are single celled or form the colonies, can be presented by naked cells or live in theca or lorica, but in ...

    Authors: Sergey A. Karpov
    Citation: Cilia 2016 5:11
  18. Oral-facial-digital syndromes (OFDS) represent a heterogeneous group of rare developmental disorders affecting the mouth, the face and the digits. Additional signs may involve brain, kidneys and other organs t...

    Authors: Brunella Franco and Christel Thauvin-Robinet
    Citation: Cilia 2016 5:12
  19. The basal body is a highly organized structure essential for the formation of cilia. Basal bodies dock to a cellular membrane through their distal appendages (also known as transition fibers) and provide the f...

    Authors: Galo Garcia III and Jeremy F. Reiter
    Citation: Cilia 2016 5:17
  20. Endocrine-cerebro-osteodysplasia (ECO) syndrome [MIM:612651] caused by a recessive mutation (p.R272Q) in Intestinal cell kinase (ICK) shows significant clinical overlap with ciliary disorders. Similarities are...

    Authors: Machteld M. Oud, Carine Bonnard, Dorus A. Mans, Umut Altunoglu, Sumanty Tohari, Alvin Yu Jin Ng, Ascia Eskin, Hane Lee, C. Anthony Rupar, Nathalie P. de Wagenaar, Ka Man Wu, Piya Lahiry, Gregory J. Pazour, Stanley F. Nelson, Robert A. Hegele, Ronald Roepman…
    Citation: Cilia 2016 5:8
  21. The amoeboflagellate Naegleria was one of the first organisms in which de novo basal body/centriole assembly was documented. When in its flagellate form, this single-celled protist has two flagella that are templ...

    Authors: Lillian K. Fritz-Laylin and Chandler Fulton
    Citation: Cilia 2016 5:10
  22. In human cells, the basal body (BB) core comprises a ninefold microtubule-triplet cylindrical structure. Distal and subdistal appendages are located at the distal end of BB, where they play indispensable roles...

    Authors: Anastassiia Vertii, Hui-Fang Hung, Heidi Hehnly and Stephen Doxsey
    Citation: Cilia 2016 5:13
  23. Trichonympha is a symbiotic flagellate of many species of termites and of the wood-feeding cockroach. Remarkably, this unicellular organism harbors up to over ten thousand flagella on its...

    Authors: Paul Guichard and Pierre Gönczy
    Citation: Cilia 2016 5:9
  24. Primary cilia are cellular protrusions involved in mechanic and chemical sensing on almost all cells of our body. Important signaling pathways, including Hedgehog, TGFβ, and Ca2+, are linked to cilia and/or cilia...

    Authors: Anneloes Dummer, Christian Poelma, Marco C. DeRuiter, Marie-José T. H. Goumans and Beerend P. Hierck
    Citation: Cilia 2016 5:7
  25. Paramecium is a free-living unicellular organism, easy to cultivate, featuring ca. 4000 motile cilia emanating from longitudinal rows of basal bodies anchored in the plasma membrane. The ...

    Authors: Anne-Marie Tassin, Michel Lemullois and Anne Aubusson-Fleury
    Citation: Cilia 2016 5:6
  26. Cancer cells are distinguished from normal cells by increased proliferation and metabolism, loss of polarity control, and the potential to invade other tissues of the body. As hubs of signaling transduction, p...

    Authors: Muqing Cao and Qing Zhong
    Citation: Cilia 2016 5:4
  27. Xenopus has been one of the earliest and most important vertebrate model organisms for investigating the role and structure of basal bodies. Early transmission electron microscopy studies...

    Authors: Siwei Zhang and Brian J. Mitchell
    Citation: Cilia 2016 5:2
  28. Tetrahymena thermophila is a ciliate with hundreds of cilia primarily used for cellular motility. These cells propel themselves by generating hydrodynamic forces through coordinated cilia...

    Authors: Brian A. Bayless, Domenico F. Galati and Chad G. Pearson
    Citation: Cilia 2016 5:1
  29. The primary cilium is a sensor of blood-induced forces in endothelial cells (ECs). Studies that have examined EC primary cilia have reported a wide range of cilia incidence (percentage of ciliated cells). We ...

    Authors: Yi Chung Lim, Sue R. McGlashan, Michael T. Cooling and David S. Long
    Citation: Cilia 2015 4:11
  30. Bardet–Biedl Syndrome (BBS) is a genetically heterogeneous ciliopathy with clinical cardinal features including retinal degeneration, obesity and renal dysfunction. To date, 20 BBS genes have been identified w...

    Authors: Noëlle Cognard, Maria J Scerbo, Cathy Obringer, Xiangxiang Yu, Fanny Costa, Elodie Haser, Dane Le, Corinne Stoetzel, Michel J Roux, Bruno Moulin, Hélène Dollfus and Vincent Marion
    Citation: Cilia 2015 4:10