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  1. Methodology

    The IN/OUT assay: a new tool to study ciliogenesis

    Nearly all cells have a primary cilia on their surface, which functions as a cellular antennae. Primary cilia assembly begins intracellularly and eventually emerges extracellularly. However, current ciliogenes...

    Ira Kukic, Felix Rivera-Molina and Derek Toomre

    Cilia 2016 5:23

    Published on: 4 August 2016

  2. Review

    Drosophila melanogaster as a model for basal body research

    The fruit fly, Drosophila melanogaster, is one of the most extensively studied organisms in biological research and has centrioles/basal bodies and cilia that can be modelled to investigate their functions in ani...

    Swadhin Chandra Jana, Mónica Bettencourt-Dias, Bénédicte Durand and Timothy L. Megraw

    Cilia 2016 5:22

    Published on: 5 July 2016

  3. Review

    The basal bodies of Chlamydomonas reinhardtii

    The unicellular green alga, Chlamydomonas reinhardtii, is a biflagellated cell that can swim or glide. C. reinhardtii cells are amenable to genetic, biochemical, proteomic, and microscopic analysis of its basal b...

    Susan K. Dutcher and Eileen T. O’Toole

    Cilia 2016 5:18

    Published on: 1 June 2016

  4. Review

    Flagellar apparatus structure of choanoflagellates

    Phylum choanoflagellata is the nearest unicellular neighbor of metazoa at the phylogenetic tree. They are single celled or form the colonies, can be presented by naked cells or live in theca or lorica, but in ...

    Sergey A. Karpov

    Cilia 2016 5:11

    Published on: 4 May 2016

  5. Review

    Update on oral-facial-digital syndromes (OFDS)

    Oral-facial-digital syndromes (OFDS) represent a heterogeneous group of rare developmental disorders affecting the mouth, the face and the digits. Additional signs may involve brain, kidneys and other organs t...

    Brunella Franco and Christel Thauvin-Robinet

    Cilia 2016 5:12

    Published on: 2 May 2016

  6. Review

    A primer on the mouse basal body

    The basal body is a highly organized structure essential for the formation of cilia. Basal bodies dock to a cellular membrane through their distal appendages (also known as transition fibers) and provide the f...

    Galo Garcia and Jeremy F. Reiter

    Cilia 2016 5:17

    Published on: 25 April 2016

  7. Research

    A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome

    Endocrine-cerebro-osteodysplasia (ECO) syndrome [MIM:612651] caused by a recessive mutation (p.R272Q) in Intestinal cell kinase (ICK) shows significant clinical overlap with ciliary disorders. Similarities are...

    Machteld M. Oud, Carine Bonnard, Dorus A. Mans, Umut Altunoglu, Sumanty Tohari, Alvin Yu Jin Ng, Ascia Eskin, Hane Lee, C. Anthony Rupar, Nathalie P. de Wagenaar, Ka Man Wu, Piya Lahiry, Gregory J. Pazour, Stanley F. Nelson, Robert A. Hegele, Ronald Roepman…

    Cilia 2016 5:8

    Published on: 11 April 2016

  8. Review

    Naegleria: a classic model for de novo basal body assembly

    The amoeboflagellate Naegleria was one of the first organisms in which de novo basal body/centriole assembly was documented. When in its flagellate form, this single-celled protist has two flagella that are templ...

    Lillian K. Fritz-Laylin and Chandler Fulton

    Cilia 2016 5:10

    Published on: 4 April 2016

  9. Review

    Human basal body basics

    In human cells, the basal body (BB) core comprises a ninefold microtubule-triplet cylindrical structure. Distal and subdistal appendages are located at the distal end of BB, where they play indispensable roles...

    Anastassiia Vertii, Hui-Fang Hung, Heidi Hehnly and Stephen Doxsey

    Cilia 2016 5:13

    Published on: 14 March 2016

  10. Review

    Basal body structure in Trichonympha

    Trichonympha is a symbiotic flagellate of many species of termites and of the wood-feeding cockroach. Remarkably, this unicellular organism harbors up to over ten thousand flagella on its...

    Paul Guichard and Pierre Gönczy

    Cilia 2016 5:9

    Published on: 1 March 2016

  11. Review

    Paramecium tetraurelia basal body structure

    Paramecium is a free-living unicellular organism, easy to cultivate, featuring ca. 4000 motile cilia emanating from longitudinal rows of basal bodies anchored in the plasma membrane. The ...

    Anne-Marie Tassin, Michel Lemullois and Anne Aubusson-Fleury

    Cilia 2016 5:6

    Published on: 8 February 2016

  12. Review

    Basal bodies in Xenopus

    Xenopus has been one of the earliest and most important vertebrate model organisms for investigating the role and structure of basal bodies. Early transmission electron microscopy studies...

    Siwei Zhang and Brian J. Mitchell

    Cilia 2016 5:2

    Published on: 3 February 2016

  13. Review

    Cilia in autophagy and cancer

    Cancer cells are distinguished from normal cells by increased proliferation and metabolism, loss of polarity control, and the potential to invade other tissues of the body. As hubs of signaling transduction, p...

    Muqing Cao and Qing Zhong

    Cilia 2016 5:4

    Published on: 3 February 2016

  14. Review

    Tetrahymena basal bodies

    Tetrahymena thermophila is a ciliate with hundreds of cilia primarily used for cellular motility. These cells propel themselves by generating hydrodynamic forces through coordinated cilia...

    Brian A. Bayless, Domenico F. Galati and Chad G. Pearson

    Cilia 2016 5:1

    Published on: 19 January 2016

  15. Review

    Current topics of functional links between primary cilia and cell cycle

    Primary cilia, microtubule-based sensory structures, orchestrate various critical signals during development and tissue homeostasis. In view of the rising interest into the reciprocal link between ciliogenesis...

    Ichiro Izawa, Hidemasa Goto, Kousuke Kasahara and Masaki Inagaki

    Cilia 2015 4:12

    Published on: 29 December 2015

  16. Research

    Culture and detection of primary cilia in endothelial cell models

    The primary cilium is a sensor of blood-induced forces in endothelial cells (ECs). Studies that have examined EC primary cilia have reported a wide range of cilia incidence (percentage of ciliated cells). We ...

    Yi Chung Lim, Sue R. McGlashan, Michael T. Cooling and David S. Long

    Cilia 2015 4:11

    Published on: 30 September 2015

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