From: Pancreatic cyst development: insights from von Hippel-Lindau disease
Reference [No.] | Knock-out gene(s) | Target cells | Age (months) | Pancreatic manifestations |
---|---|---|---|---|
[71] | Vhlh | Progenitor | 6-8 | None |
[73] | Vhlh | Progenitor | 12 | Increased pancreatic vascularization |
[71] | Vhlh | Progenitor | 16-18 | Cysts, microcystic adenomas, fat depositions, abnormal shaped and hyper-vascular islet cells |
[71] | Vhlh | Endocrine α | 10-23 | None |
[71] | Vhlh | Endocrine β | 15 | None |
[73] | Vhlh | Endocrine β | 12 | Increased vascularization in islets |
[72] | Vhlh | Endocrine β | 6.5 | None |
[72] | Vhlh; Hif-1α | Endocrine β | 6.5 | None |
[72] | Hif-1α | Endocrine β | 6.5 | None |
[74] | Vhlh | Endocrine β | N/A | Increased vascularization in islets |
[75] | Vhlh | Endocrine β | 2 | Increased vascularization and α-cells scattered throughout the islets |
[66] | Kif3a | Progenitor | 2 | Compromised acinar tissue |
[66] | Kif3a | Progenitor | 12 | Fibrosis, ductal dilation, cysts |