Figure 4

Mirror image in the function of outer arm dynein Ca ²⁺ sensors between Ciona and Chlamydomonas . Ciona calaxin binds to the β-heavy chain, suppresses microtubule-sliding and induces propagation of an asymmetric waveform at high concentration of Ca²⁺. In contrast, Chlamydomonas LC4 binds to the γ-heavy chain, becomes tethered to IC1 and induces propagation of a symmetric waveform at high concentration of Ca²⁺. Direct evidence for the activation of microtubule-sliding by Chlamydomonas outer arm dynein has not been obtained.