Volume 1 Supplement 1

Proceedings of the First International Cilia in Development and Disease Scientific Conference (2012)

Open Access

Planar cell polarity, cilia, and human disease

Cilia20121(Suppl 1):K2

https://doi.org/10.1186/2046-2530-1-S1-K2

Published: 16 November 2012

The planar cell polarity (PCP) proteins govern diverse cellular behaviors, are essential for embryonic development, and are associated in a variety of human birth defects, including ciliopathies. While many PCP proteins have been extensively characterized, the “PCP effector” proteins, Inturned, Fuzzy and Fritz, remain largely unstudied. We have shown that each of these novel proteins is broadly essential for ciliogenesis in vertebrate animals. Here, we will discuss our efforts to combine bioinformatics, genomics, mouse genetics, and in vivo time-lapse imaging of intraflagellar transport to understand the mechanisms by which the PCP proteins govern cilia structure and function.

Authors’ Affiliations

(1)
University of Texas

Copyright

© Wallingford; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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