Skip to main content
  • Keynote lecture presentation
  • Open access
  • Published:

Planar cell polarity, cilia, and human disease

The planar cell polarity (PCP) proteins govern diverse cellular behaviors, are essential for embryonic development, and are associated in a variety of human birth defects, including ciliopathies. While many PCP proteins have been extensively characterized, the “PCP effector” proteins, Inturned, Fuzzy and Fritz, remain largely unstudied. We have shown that each of these novel proteins is broadly essential for ciliogenesis in vertebrate animals. Here, we will discuss our efforts to combine bioinformatics, genomics, mouse genetics, and in vivo time-lapse imaging of intraflagellar transport to understand the mechanisms by which the PCP proteins govern cilia structure and function.

Author information

Authors and Affiliations


Corresponding author

Correspondence to JB Wallingford.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

Wallingford, J. Planar cell polarity, cilia, and human disease. Cilia 1 (Suppl 1), K2 (2012).

Download citation

  • Published:

  • DOI: