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Cilia

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  1. Content type: Research

    Recent research into ciliary structure and function provides important insights into inherited diseases termed ciliopathies and other cilia-related disorders. This wealth of knowledge needs to be translated in...

    Authors: Paola Roncaglia, Teunis J. P. van Dam, Karen R. Christie, Lora Nacheva, Grischa Toedt, Martijn A. Huynen, Rachael P. Huntley, Toby J. Gibson and Jane Lomax

    Citation: Cilia 2017 6:10

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  2. Content type: Review

    Cilia appear to be derived, evolutionarily, from structures present in the ancestral (pre-ciliary) eukaryote, such as microtubule-based vesicle trafficking and chromosome segregation systems. Experimental obse...

    Authors: Tristan D. McClure-Begley and Michael W. Klymkowsky

    Citation: Cilia 2017 6:8

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  3. Content type: Research

    Skeletal ciliopathies comprise a spectrum of ciliary malfunction disorders that have a profound effect on the skeleton. Most common among these disorders is short rib polydactyly syndrome (SRPS), a recessively...

    Authors: Ivan Duran, S. Paige Taylor, Wenjuan Zhang, Jorge Martin, Faisal Qureshi, Suzanne M. Jacques, Robert Wallerstein, Ralph S. Lachman, Deborah A. Nickerson, Michael Bamshad, Daniel H. Cohn and Deborah Krakow

    Citation: Cilia 2017 6:7

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  4. Content type: Research

    The development of a ciliary axoneme requires the correct docking of the basal body at cytoplasmic vesicles or plasma membrane. In the multiciliated cell Paramecium, three conserved proteins, FOR20, Centrin 2, an...

    Authors: Hakim Bengueddach, Michel Lemullois, Anne Aubusson-Fleury and France Koll

    Citation: Cilia 2017 6:6

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  5. Content type: Research

    La-related protein 6 (LARP6) is an evolutionally conserved RNA-binding protein. Vertebrate LARP6 binds the 5′ stem-loop found in mRNAs encoding type I collagen to regulate their translation, but other target m...

    Authors: Zarko Manojlovic, Ryan Earwood, Akiko Kato, Diana Perez, Oscar A. Cabrera, Ruth Didier, Timothy L. Megraw, Branko Stefanovic and Yoichi Kato

    Citation: Cilia 2017 6:4

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  6. Content type: Research

    Three-dimensional explant spheroid formation is an ex vivo technique previously used in studies of airway epithelial ion and water transport. Explanted cells and sheets of nasal epithelium form fully different...

    Authors: June Kehlet Marthin, Elizabeth Munkebjerg Stevens, Lars Allan Larsen, Søren Tvorup Christensen and Kim Gjerum Nielsen

    Citation: Cilia 2017 6:3

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  7. Content type: Research

    The discovery of disease pathogenesis requires systematic agnostic screening of multiple homeostatic processes that may become deregulated. We illustrate this principle in the evaluation and diagnosis of a 5-y...

    Authors: Megan S. Kane, Mariska Davids, Michelle R. Bond, Christopher J. Adams, Megan E. Grout, Ian G. Phelps, Diana R. O’Day, Jennifer C. Dempsey, Xeuli Li, Gretchen Golas, Gilbert Vezina, Meral Gunay-Aygun, John A. Hanover, Dan Doherty, Miao He, May Christine V. Malicdan…

    Citation: Cilia 2017 6:2

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  8. Content type: Review

    This is a history of cilia research before and after the discovery of intraflagellar transport (IFT) and the link between primary cilia ciliogenesis and polycystic kidney disease (PKD). Before IFT, ca. the beg...

    Authors: Peter Satir

    Citation: Cilia 2017 6:1

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  9. Content type: Methodology

    Nearly all cells have a primary cilia on their surface, which functions as a cellular antennae. Primary cilia assembly begins intracellularly and eventually emerges extracellularly. However, current ciliogenes...

    Authors: Ira Kukic, Felix Rivera-Molina and Derek Toomre

    Citation: Cilia 2016 5:23

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  10. Content type: Review

    The fruit fly, Drosophila melanogaster, is one of the most extensively studied organisms in biological research and has centrioles/basal bodies and cilia that can be modelled to investigate their functions in ani...

    Authors: Swadhin Chandra Jana, Mónica Bettencourt-Dias, Bénédicte Durand and Timothy L. Megraw

    Citation: Cilia 2016 5:22

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  11. Content type: Review

    The unicellular green alga, Chlamydomonas reinhardtii, is a biflagellated cell that can swim or glide. C. reinhardtii cells are amenable to genetic, biochemical, proteomic, and microscopic analysis of its basal b...

    Authors: Susan K. Dutcher and Eileen T. O’Toole

    Citation: Cilia 2016 5:18

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  12. Content type: Review

    Phylum choanoflagellata is the nearest unicellular neighbor of metazoa at the phylogenetic tree. They are single celled or form the colonies, can be presented by naked cells or live in theca or lorica, but in ...

    Authors: Sergey A. Karpov

    Citation: Cilia 2016 5:11

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  13. Content type: Review

    Oral-facial-digital syndromes (OFDS) represent a heterogeneous group of rare developmental disorders affecting the mouth, the face and the digits. Additional signs may involve brain, kidneys and other organs t...

    Authors: Brunella Franco and Christel Thauvin-Robinet

    Citation: Cilia 2016 5:12

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  14. Content type: Review

    The basal body is a highly organized structure essential for the formation of cilia. Basal bodies dock to a cellular membrane through their distal appendages (also known as transition fibers) and provide the f...

    Authors: Galo Garcia III and Jeremy F. Reiter

    Citation: Cilia 2016 5:17

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  15. Content type: Research

    Endocrine-cerebro-osteodysplasia (ECO) syndrome [MIM:612651] caused by a recessive mutation (p.R272Q) in Intestinal cell kinase (ICK) shows significant clinical overlap with ciliary disorders. Similarities are...

    Authors: Machteld M. Oud, Carine Bonnard, Dorus A. Mans, Umut Altunoglu, Sumanty Tohari, Alvin Yu Jin Ng, Ascia Eskin, Hane Lee, C. Anthony Rupar, Nathalie P. de Wagenaar, Ka Man Wu, Piya Lahiry, Gregory J. Pazour, Stanley F. Nelson, Robert A. Hegele, Ronald Roepman…

    Citation: Cilia 2016 5:8

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  16. Content type: Review

    The amoeboflagellate Naegleria was one of the first organisms in which de novo basal body/centriole assembly was documented. When in its flagellate form, this single-celled protist has two flagella that are templ...

    Authors: Lillian K. Fritz-Laylin and Chandler Fulton

    Citation: Cilia 2016 5:10

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  17. Content type: Review

    In human cells, the basal body (BB) core comprises a ninefold microtubule-triplet cylindrical structure. Distal and subdistal appendages are located at the distal end of BB, where they play indispensable roles...

    Authors: Anastassiia Vertii, Hui-Fang Hung, Heidi Hehnly and Stephen Doxsey

    Citation: Cilia 2016 5:13

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