Table 2 VHL (related) pancreatic knock-out mouse models

[71]

Vhlh

Progenitor

6-8

None

[73]

Vhlh

Progenitor

12

Increased pancreatic vascularization

[71]

Vhlh

Progenitor

16-18

Cysts, microcystic adenomas, fat depositions, abnormal shaped and hyper-vascular islet cells

[71]

Vhlh

Endocrine α

10-23

None

[71]

Vhlh

Endocrine β

15

None

[73]

Vhlh

Endocrine β

12

Increased vascularization in islets

[72]

Vhlh

Endocrine β

6.5

None

[72]

Vhlh; Hif-1α

Endocrine β

6.5

None

[72]

Hif-1α

Endocrine β

6.5

None

[74]

Vhlh

Endocrine β

N/A

Increased vascularization in islets

[75]

Vhlh

Endocrine β

2

Increased vascularization and α-cells scattered throughout the islets

[66]

Kif3a

Progenitor

2

Compromised acinar tissue

[66]

Kif3a

Progenitor

12

Fibrosis, ductal dilation, cysts