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Figure 1 | Cilia

Figure 1

From: Remodeling Cildb, a popular database for cilia and links for ciliopathies

Figure 1

The species whose whole proteome has been included into Cildb V3.0 aregathered by taxonomy groups, with indication whether they are centric or notand of the number of high throughput studies, ciliary or not, performed inthe species. The choice of species to include into Cildb was 1) speciesin which high throughput ciliary studies have been performed, 2) speciesroutinely used as models in ciliary studies in general, and 3) centric andacentric species, because the presence/absence of certain proteins may berelevant for the conservation of ciliary proteins through evolution. The caseof the Bug22/GTL3/C16orf80 protein, composed of a domain called DUF667,essential for ciliary motility [6], wascarefully examined for the choice of fungi to add in Cildb for comparativegenomics. Bug22 is a protein highly conserved in all centric species, be theymetazoans, protozoa, plants or fungi and curiously also highly conserved in theacentric land plants, but absent from the genomes of higher fungi alreadysequenced at the time of the publication, i.e. acentric ascomycetes[6]. Owing to constant new genomesequencing, novel fungal whole proteomes appeared and the occurrence of Bug22was different from what was thought earlier. It is still undetectable inascomycetes, but is found conserved in the acentric Mortierellaverticillata (accession MVEG_01915), and a more divergent Bug22 withrecognizable DUF667 domain is found in several basidiomycetes represented inCildb by Laccaria bicolor (accession 598201). This property was one ofthe reasons to include those two fungi proteomes into Cildb V3.0. This alsoemphasizes that constant arrival of new knowledge as new genomes are sequencedcan put into questions former assumptions such as the absence of particularproteins in some species, here Bug22 in fungi.

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