Fig. 5

Growth plate defects in IFT43 SRPS. a–c Picrosirius red and hematoxylin staining of cartilage growth plates in control and affected patients. d–f Expansion of boxed regions in a–c. Note the irregular column formation and lack of normal progressive enlargement of hypertrophic chondrocytes in both R06-303A and R03-121A. Arrows identify regions with retained cartilage in the primary spongiosum. g–i are magnifications in d–f, respectively showing polarity disruption in proliferating columns in patient samples. Scale bars, 50 μm. g–i pictures are also 50 μm wide