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This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
This article is part of a Supplement: Volume 1 Supplement 1
Tubby is the founding member of the tubby-like family of proteins. The naturally occurring tubby mutation in mice causes retinitis pigmentosa, hearing loss and obesity. Tubby has been proposed to function as an a...
Clusterin associated protein 1 (CLUAP1) was initially characterized as a protein that interacts with clusterin, and whose gene is frequently upregulated in colon cancer. Although the consequences of these observa...
Primary cilia are present on almost all vertebrate cells, and they have diverse functions in distinct tissues. Cilia are important for sensation in multiple capacities in contexts as different as the retina, k...
Meckel-Gruber syndrome (MKS) is an autosomal recessive lethal condition that is a ciliopathy. MKS has marked phenotypic variability and genetic heterogeneity, with mutations in nine genes identified as causati...
Most cells in the body possess a single primary cilium. These cilia are key transducers of sensory stimuli, and defects in cilia have been linked to several diseases. Evidence suggests that some transduction o...
Changes in genes coding for ciliary proteins contribute to complex human syndromes called ciliopathies, such as Bardet-Biedl Syndrome (BBS). We used the model organism Paramecium to focus on ciliary ion channels ...
Ovarian cancer is the fourth leading cause of cancer-related deaths among women in Denmark, largely due to the advanced stage at diagnosis in most patients. Approximately 90% of ovarian cancers originate from ...
Analysis of ciliary function for assessment of patients suspected of primary ciliary dyskinesia (PCD) and for research studies of respiratory and ependymal cilia requires assessment of both ciliary beat patter...
Park2-co-regulated gene (PACRG) is evolutionarily highly conserved from green algae to mammals. In Chlamydomonas and trypanosomes, the PACRG protein associates with flagella. Loss of PACRG results in shortened or...
The effect of anesthetic agents on ependymal ciliary function is unknown. The aim of this study was to determine the effect of halothane and pentobarbital sodium on brain ependymal ciliary function.
Primary cilia length is an important measure of cell and tissue function. While accurate length measurements can be calculated from cells in 2D culture, measurements in tissue or 3D culture are inherently diff...
Recent studies of the primary cilium have begun to provide further insights into ciliary ultrastructure, with an emerging picture of complex compartmentalization and molecular components that combine in functi...
Ever since Edouard Van Beneden and Theodor Boveri first formally described the centrosome in the late 1800s, it has captivated cell biologists. The name clearly indicated its central importance to cell functio...
The aim of this study was to compare beat frequency measurements of ependymal cilia made by digital high speed imaging to those obtained using the photomultiplier and modified photodiode techniques. Using high...
Primary cilia have recently been highlighted as key regulators in development and disease. This review focuses on current work demonstrating the broad role of cilia-related proteins in developmental signaling ...
Primary cilia are microtubule-based sensory organelles that play important roles in developmental signaling pathways. Recent work demonstrated that, in cell culture, the daughter cell that inherits the older m...
Polarized vesicle trafficking is mediated by small GTPase proteins, such as Rabs and Arls/Arfs. These proteins have essential roles in maintaining normal cellular function, in part, through regulating intracel...
The central tenet of cilia function is sensing and transmitting information. The capacity to directly contact extracellular surfaces would empower primary cilia to probe the environment for information about t...
Mutations in the gene for Usher syndrome 2A (USH2A) are causative for non-syndromic retinitis pigmentosa and Usher syndrome, a condition that is the most common cause of combined deaf-blindness. To gain insight i...